ERstress相关论文
目的:乳腺癌是目前全球女性最常见的恶性肿瘤,研究表明糖尿病与乳腺癌的发生发展密切相关,是乳腺癌的高危因素。越来越多的研究发......
Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce auto
Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8......
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification i
Previous reports suggested that cinnamaldehyde(CA),the bioactive ingredient in Cinnamomum cassia,can suppress tumor grow......
Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liv
Metabolic-associated fatty liver disease(MAFLD)is the most common metabolic disease with a global prevalence of 25％.While......
研究背景据统计,中国60岁及以上人群中阿尔茨海默症（Alzheimerdisease,AD）患者约为983万人[1],AD为中国愈加严重的老龄化社会带来了......
Cancer cells are often exposed to cell intrinsic stresses and environmental perturbations that may lead to accumulation ......
ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and
Ferroptotic cell death is characterized by iron-dependent lipid peroxidation that is initiated by ferrous iron and H2O2 ......
A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endo
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases and increases mortality in type 2 ......
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Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/ Frontotemporal Dementia Causes Neurotoxici
GGGGCC repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotempor......
Methylseleninic acid(MSA)potentiates Bortezomib induced-ER stress and sensitizes apoptosis in multip
Previous studies showed that MSA could induce ER stress which is severe enough to cause apoptosis,and we have shown that......
骨肉瘤干细胞是其化疗耐药、肿瘤复发和转移的根源。因此,亟需深入了解骨肉瘤干细胞生物学特性并探索新的靶向治疗策略。通过对骨......
目的 弥漫大细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL),是成人非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)中最常见的一种......
目的 The accumulate evidence show that the fluidity of cell membrane could affect cancer progression in different solid ......
Chop Deficiency Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macroph
目的 Idiopathic pulmonary fibrosis (IPF) is a severe health problem worldwide and has one of the poorest prognoses.C/EBP......
Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation by PERK-ATF4-CHOP Signal
Objective Endoplasmic Reticulum(ER)stress has been considered as an important regulator of airway inflammation in the pa......
Neuron specific ApoE4(1-272)fragment triggers ER stresss-induced apopotosis and contributes to the p
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α-Synuclein(α-Syn)is the most abundant protein found in Lewy bodies,a hallmark of Parkinsons disease(PD).Pathological ......
Introduction: Nicotinamide phosphoribosyltransferase(Nampt)is a crucial coenzyme in cellular redox reactions.Inside the ......
Aim: 5 Adenosine monophosphate-activated protein kinase (AMPK) was reported to form transcriptional complex with peroxis......
Background and Purpose: Relative to the mature brain, the neonatal brain has shown increased resistance to hypoxia-ische......
Ginkgolide K protects cardiomyocytes against ER stress through stimulating ER-associated degradation
Aim Endoplasmic reticulum (ER) stress is increasingly recognized as an important contributor to the pathophysiology of m......
Taurine,a conditional essential amino acid,plays a critical role in cardiovascular functions.Here we examined the effect......
The orphan nuclear receptor NR4A1 (also known as Nur77,NGFI-B,TR3,TIS1,NAK-1,or N10) is a unique transcription factor en......
Endoplasmic reticulum stress involved in renal autophagy and dysfunction triggered by CdTe-quantum d
Quantum dots(QDs)have been widely employed in biomedical applications including biosensors,biomedical imaging,and drug d......
B19,a novel monocarbonyl analogue of curcumin,inducesros-mediated apoptosis via targeting TrxR1 in g
The thioredoxin reductase(TrxR)1 is often overexpressed in numerous cancer cells.Targeting TrxR1 leads to a reduction in......
目的：Oxidative stress is a common pathological background for different etiologies of spontaneous abortion.It has been su......
Purpose:Autophagy is the major regulated mechanism for degrading long lived proteins and the only known pathway for degr......
CHOP and JNK mediate radiation-induced Apoptosis and Autophagy via unfolded protein response in Brea
Background and purpose:Endoplasmic reticulum(ER)stress generated by various physiological and pathological conditions ma......
Role of endoplasmic reticulum stress in the cardioprotection of vasonatrin peptide against myocardia
Introduction: This study was to observe the effects of vasonatrin peptide (VNP) on myocardial ischemia/reperfusion (MI/R......
Celastrol, a bioaetive compound extracted from Tripterygium wilfordii Hook F., has recently attracted much attention for......
S-adenosylhomocysteine Accumulation Promotes Atherosclerosis by Epigenetic Regulation of Endoplasmic
Aim S-adenosylhomocysteine (SAH) is involved in the epigenetic mechanism of hyperhomocysteinemia pathogenicity of athero......
OBJECTIVE Garcinone E, a xanthone derivative isolated from mangosteen, has been reported to have cytotoxic capacities.We......
HIV protease inhibitors sensitize human head and neck carcinoma cells to radiation by activating end
Aim Head and neck cancers are the eighth most common cancer worldwide.Despite significant advances in the delivery of tr......
Aims: Apelin is the endogenous ligand for the G protein coupled receptor APJ.It promotes vascular smooth muscle cell pro......
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Induction of autophagy reduces markers of renal endoplasmic reticulum stress in Glycogen Storage Dis
Glycogen Storage Disorder Type la (GSD1a), also known as von Gierkes disease, is the most common Glycogen Storage Disord......
Novel functions of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T): Regulatio
O-GalNAc glycosylation is an important protein posttranslational modification which plays critical roles in cell-cell co......
Protein folding is a fundamental process in eukaryotic cells.When unfolded or misfolded proteins accumulate in the endop......
Mitochondria homeostasis is critical for neuronal survival.In ischemic brains,damaged mitochondria lead to neuronal cell......
Alisol B induced endoplasmic reticulum stress and activated a protective NF-κB nuclear translocation
Objective: Emerging evidence suggests the natural products and compounds have bioactivity to induce cancer cells apoptot......
Alisol B induces endoplasmic reticulum stress and activates a protective NF-κB nuclear translocation
Objective: Emerging evidence suggests that the natural products have the bioactivity to induce cancer cells apoptotic de......
Autophagy induced by radiation is critical to cell fate decision.Evidence now sheds light on the importance of autophagy......
Here we investigated the effects and the underlying mechanism of Ginkgolide K(1,10-dihydroxy-3,14-didehydroginkgolide,GK......
OBJECTIVE Here we investigated the effects and the underlying mechanism of Ginkgolide K (1,10-dihydroxy-3, 14-didehydrog......
Endoplasmic reticulum (ER) stress is increasingly recognized as an important causal factor of many diseases.Targeting ER......
Chronic inhibition of cyclic GMP phosphodiesterase 5 suppresses endoplasmic reticulum stress in hear
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Objective Carbonic anhydrase Ⅰ (CA Ⅰ) protein levels were found to be significantly increased in the spinal cords of b......
